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Most total B12 assays capture the vitamin with intrinsic factor rather than an antibody, so these assays are generally not vulnerable to heterophile-antibody interference the way antibody-based assays are

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J Biol Chem 249:21752181 Awad J, Stotz HU, Fekete A, Krischke M, Engert C, Havaux M, Berger S, Mueller MJ (2015) 2-Cysteine peroxiredoxins and thylakoid ascorbate peroxidase create a water-water cycle that is essential to protect the photosynthetic apparatus under high light stress conditions