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Clinical data supports its efficacy for: depression (comparable to some antidepressants in RCTs), osteoarthritis, liver disease (non-alcoholic fatty liver), and homocysteine-related conditions

TABLE 1 Detailed information regarding studies and datasets used in the present study

If you are on a split dosing schedule , the timing becomes more complex

Note that the velocity of the DNA methylation reaction (DNMT in Panel C) is also quite stable despite the fact that its substrate, SAM, is undergoing very large fluctuations

In a 60-day human trial, women taking 20 mg per day reported a 47% drop in perceived stress and a 10.7% drop in anxiety

4 Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, Peoples Republic of China