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Particles can come from: Degraded peptide forming insoluble aggregates Contamination during manufacturing or storage Rubber stopper fragments from repeated needle punctures Crystallization of dissolved components If you see particles, do not try to filter them out

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Compare that to just 2.4% with placebo

Injecting into areas with insufficient subcutaneous fat increases the risk of intramuscular injection

While localized issues may still pop up, the large-scale shortages of recent years appear to be resolving as manufacturers ramp up production