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Curated affinity data instead describe a full agonist at four of the five human melanocortin receptors: reported pIC 10.0 at MC1R, pKi 8.9 at MC3R, pKi 8.5 to 8.8 at MC4R, and pIC 9.0 at MC5R, with no activity at MC2R, the adrenocorticotropin receptor, which is not engaged by alpha-MSH analogues of this class

J Dermatol Sci 102(1):25-35 Zoller N, Valesky E, Hofmann M, Bereiter-Hahn J, Bernd A, Kaufmann R, Meissner M, Kippenberger S (2015) Impact of different spa waters on inflammation parameters in human keratinocyte HaCaT cells

G.et al (2023)

Nitric oxide, superoxide, and peroxynitrite in CNS injury

International Journal of Biological Macromolecules, 253 , 127554

The rest of this guide breaks down how dosage changes by administration route, how to match your protocol to your goal, what to expect week by week, and when to cycle BPC-157 for best results