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A 2024 paper in Physiology & Behavior characterised that ipamorelin and the related GHSR-1a agonist anamorelin inhibited cisplatin-induced weight loss in ferrets, framing one route by which the GHSR-1a agonist class engages cachexia research (PMID 39043357)
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Macrophage plasticity, polarization, and function in health and disease
Clinical studies show this multi-system approach produces weight loss averaging 1522% of baseline body weight over six months to one year
Patients must demonstrate a commitment to making lifestyle changes while taking the medication or else it may not be prescribed by their doctor
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