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References Rocha RI, Junior WC, Modolin MLA, Takahashi GG, Caldini ETEG, Gemperli R

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[7] In a Bayesian network meta-analysis of 48 randomized trials and nearly 28,000 participants, the dominant gastrointestinal events were nausea (about 21.5%), diarrhea (10.6%), vomiting (9.1%), and constipation (7.9%), with semaglutide carrying one of the highest constipation risks

Such molecules elicit glycemic benefits in mice without concomitant increases in signs of nausea, a common side effect of GLP-1 therapies

Pagliuca FW, Millman JR, Gurtler M, et al