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Similar to other RING-between-RING E3 ligases, Parkin forms a ubiquitin-thioester intermediate at the active site Cys431 and transfers ubiquitin to substrates [120]
Consequently, a deficiency in C4B protein in patients may impair its ability to bind microbial antigens
Others maintain full doses of each
Shayna Sandhaus, PhD
RD: Writing review & editing
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