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GLP-1 receptors are present in the brains reward pathways, which raises the possibility that these drugs might reduce not only overeating but also other compulsive or reward-seeking behaviors
It's the most common health goal but also likely the most abandoned one, in part because of overly restrictive dietary regimens or sometimes life just getting in the way
Importantly, TNF type 1 receptor knockout mice are resistant to the initiation and progression of NAFLD in response to both high-carbohydrate and methionine- and choline-deficient diets 26,27
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In the STEP 1 clinical trial (NEJM, 2021), participants on semaglutide 2.4 mg lost an average of 14.9% of body weight at 68 weeks (about 33.6 lbs from a 232 lb average baseline) vs 2.4% with placebo
