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The Warburg effect is a metabolic process in which tumor cells convert glucose to lactate, even in the presence of oxygen, which promotes tumor progression (82)

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For genetically predicted acetyl-carnitine, we also found an association with higher triglycerides (0.06, 95% CI 0.04 to 0.07) and lower HDL-cholesterol ( 0.03, 95% CI 0.05 to 0.02) (Additional file 2: Fig

However, lixisenatide in the ELIXA trial did not significantly alter the incidence of MACE, and exnatide in the EXSCEL trial lower the risk of MACE with no significant difference