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Abbreviations AED: antiepileptic drug CNS: central nervous system CoA: coenzyme A CPS: carbamyl phosphate synthase GABA: -aminobutyric acid NAGA: N -acetyl glutamic acid NMDA: N -methyl-D-aspartate PCT: palmityl carnitine transferase VHE: VPA-induced hyperammonaemic encephalopathy VHT: VPA-induced hepatotoxicity VPA: valproic acid

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33,34 With growing evidence of the limitations of conventional pharmacological agents and a surge in functional GI disorders, there is renewed interest in these systems

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It is possible that the binding mode for ipratropium to the outward-facing conformation may be different to that observed here

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