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Participants were randomly assigned, 1:1:1, to once-weekly combination cagrilintide and semaglutide 2.4 mg, once-weekly semaglutide 2.4 mg plus placebo or once-weekly cagrilintide 2.4 mg plus placebo

For longer use (3+ months), consider cycling

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These factors collectively reduce bioavailability and often necessitate high or modified dosing strategies in experimental studies