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Excess of chromosomes leads to overexpression of the SOD1 gene, and to elevated H 2 O 2 levels that cannot be completely eliminated by CAT and GPx, so overproduction of ROS occurs (Figure 2) [22, 23, 24, 25]

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Barth, MD (AA, University of Kansas School of Medicine, 1994) Tristan Lim Class of 2022, Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania The Role of Germline Mutations in POT1 Gene in Myeloid Neoplasms Mentor: Daria Babushok, MD, PhD (AA, Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, 2008) Councilor: Jon B