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For example, under combined heat and epigenetic stress, ONSEN (an LTR/Copia retrotransposon in Arabidopsis) generates eccDNA, but only when these stressors are applied together, highlighting the stimulus-specific and context-dependent nature of eccDNA formation (Merkulov et al., 2023)
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There are some concerns around use of the GLP-1 agents, such as weight regain after stopping treatment, the potential for a loss of skeletal muscle mass, long-term adherence, and the limited evidence that exists for long-term safety, Moiz et al say
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