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KPV inhibits NF-kB, the master switch for inflammatory gene expression in the body

Genetic and environmental factors Genetic predisposition also plays a role in the onset of this condition

Key takeaways: Estrogen is a hormone that turns on or off the transcription of estrogen-responsive genes, many of which are involved in cell growth

This cycle is what keeps the discomfort thriving and can eventually lead to the breakdown of cartilage and bone

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