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Also, there is lack of literature evaluating its efficacy.[] IV administered GSH is not directly utilized by cells but is cleaved into its component amino acids and is resynthesized to GSH intracellularly after transmembrane transport
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In the context of these concerns, the World Health Organization advises against the consumption of ethanolic and acetonic kavalactone extracts, and says that "products should be developed from water-based suspensions of kava"
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