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Titration was started slowly for the first two patients, from 1 mg d 1 up to 10 mg d 1 and then up to 50 mg d 1 with concentrations of 10 mg ml 1 , and then from 54 mg d 1 up to 90 mg d 1 with a concentration of 50 mg ml 1

Dose Rate: Lambs: 0.5 mL at marking or weaning Sheep: 1.0 1.5 mL pre-lambing Calves: 2 3 mL from 2 months of age Cows: 4 6 mL pre-calving The frequency of dosing should be related to the severity of the deficiencies

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But doctors point out these experimental compounds are highly unregulated and not ready for prime time

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