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Gq/PLC Calcium Mobilization Ipamorelin binds GHSR-1a and activates the Gq protein subunit phospholipase C beta (PLC) cleaves PIP2 into IP3 and DAG IP3 triggers calcium release from the endoplasmic reticulum of somatotroph cells intracellular calcium surge drives GH vesicle fusion and secretion

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Research published in Growth Hormone & IGF Research shows that ipamorelin dose-dependently increased longitudinal bone growth rate (LGR) in adult female rats