Since Zepbound (tirzepatide) affects how your digestive system works, it can lead to uncomfortable symptoms such as stomach pain, nausea, bloating, or cramping
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Patients are encouraged to report any unexpected side effects from either treatment to the MHRA via the Yellow Card scheme (yellowcard.mhra.gov.uk), which plays a vital role in post-market safety surveillance and helps build the evidence base for emerging therapies such as retatrutide
Clinical data shows emotional symptoms are infrequent and often related to rapid weight loss or metabolic changes rather than the medication itself
REDEFINE 2: Efficacy in Type 2 Diabetes REDEFINE 2, announced in March 2025, addressed a distinct population: 1,206 adults with obesity or overweight and type 2 diabetes across 12 countries, randomised in a 3:1 ratio to CagriSema or placebo for 68 weeks
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