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This gradual titration is designed to minimise gastrointestinal side effects, but it also allows the body time to adjust metabolically

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It can lead to changes in urination patterns, which are generally temporary

Without it Im lucky to be below the low 90s, but typically 105-110 range

It is acknowledged that activation of STAT3 which is crucial to M2 phenotype transformation, while STAT1 activity which is a key determinant for the M1 subtype