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Recognition of obesity as a disease H-440.842

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Drug interactions: Certain medications, such as omeprazole, lansoprazole, cimetidine, and metformin, can lead to low vitamin B12 levels

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Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation

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A study found that by enhancing FAO and TCA cycles, Sp1-mediated PGE2 up-regulation increased mitochondrial ATP production, leading to glioblastoma (GBM) cell resistance to temozolomide [112]

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