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Interestingly, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) suggested that patients achieving prediabetes remission differed from non-responders in improvement in whole body insulin sensitivity, visceral adipose tissue (VAT) and intrahepatic fat rather than insulin secretion upon a similar weight loss 76

This is harder on GLP-1s because your appetite is suppressedyou need to prioritize protein even when you don't feel like eating

Celletti, J

However, this combination should be done under the supervision of a healthcare provider

Preclinical studies offer additional clues

Mechanistic studies suggest that combined receptor activation may influence multiple components of glucose homeostasis, including insulin secretion pathways, peripheral insulin signaling, and hepatic glucose metabolism