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CAA commonly presents with: Lobar cerebral microbleeds Cortical superficial siderosis Lobar intracerebral hemorrhage Cognitive impairment Unlike hypertensive arteriopathy, which predominantly affects deep perforating vessels, CAA preferentially involves cortical and leptomeningeal vessels

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The core mechanism of osteoporosis (imbalance of bone metabolism) Osteoporosis is essentially a negative balance between bone formation and bone resorption, resulting in continuous loss of bone mass, destruction of bone microstructure, increased bone fragility, and increased risk of fractures

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