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In a 12-week trial of mecasermin rinfabate (IPLEX) in adults with ALS (N=330), symptomatic hypoglycaemia occurred in 6.8% of the active arm versus 2.4% of placebo [16]
In one study, 74.2% of patients on a GLP-1 reported GI symptoms
However, oral semaglutide has demonstrated impressive results in its own right
In general, a urine flow rate of less than 1 L per day increases the risk of stone formation (Curhan 2012), and guidelines for people with a history of kidney stones include the recommendation to maintain their urine output above 2 L per day (Antonelli 2015)
Given the absence of formal guidelines for combination therapy, a multidisciplinary panel of endocrinologists, nephrologists, and cardiologists convened to discuss the findings of this comprehensive analysis using the nominal group technique (NGT)
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