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Our finding that tirzepatide increases glucagon secretion in isolated islets not only demonstrates meaningful activity at the GIPR but also provides evidence that tirzepatide can overcome the activity at the GLP-1R on glucagon secretion in human islets

Moving these compounds into human trials would require substantial additional preclinical safety data, regulatory approval, and funding none of which currently exists for varicose vein applications

Jiang, J

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Despite BPC-157s short half-life in blood, its effects on tissue repair persist much longer