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Its original characterisation used isolated amphibian and reptilian skin bioassays before the cloned human receptors were available, and those historic potency data remain the reason the compound is described as superpotent in the older literature
doi:10.1586/14787210.2015.1064309 Piller T, De Vooght L, Gansemans Y, Van Nieuwerburgh F, Cos P
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