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Gradual dose escalation is necessary to build efficacy and allow patients to reach the higher maintenance doses safely while managing tolerability

However, this approach has also impacted Type 2 diabetes patients access to GLP-1s by requiring some patients to try other diabetes treatments (e.g., blood sugar regulators such as sodium-glucose cotransporter-2 inhibitor Brenzavvy and dipeptidyl peptidase-4 inhibitor Onglyza) before GLP-1 approval

Celine Gounder hit on a new example of one of my longtime pet peeves with flawed health care journalism - the use of relative, but not absolute risk reduction numbers

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