glp-1 kidney disease Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic through dampening the receptor for advanced glycation end products–induced inflammation GLP1 Receptor Agonists vs SGLT2-I

upregulation of collagen, elastin, decorin, and glycosaminoglycan synthesis

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Image Credit: azimmytws / Shutterstock.com A recent BMJ study determines whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists by type 2 diabetes (T2D) patients increases the risk of self-harm, suicidal ideation, and suicide as compared to patients prescribed dipeptidyl peptidase-4 (DPP-4) or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

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There were reductions in septic shock, liver failure, schizophrenia, opioid use disorders, alcohol use disorders, hemorrhagic stroke, suicidal ideation, and pulmonary embolism