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Oral semaglutide eliminates injection discomfort entirely, though patients must follow strict administration guidelines (fasting, specific timing, no food for 30 minutes post-dose) to ensure absorption

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Reference: Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018)

These include: Pain, redness, or swelling at the injection site Bruising or hardening of tissue (induration) Itching or warmth around the injection area Temporary discolouration of the skin These localised reactions typically resolve within 2472 hours

After 28 days, the preservative may not be strong enough to prevent bacterial growth