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A key extrinsic pathway component is the death receptor Fas (CD95), which, upon binding to Fas ligand (FasL/CD95L), recruits the adaptor protein FADD (Fas-associated death domain protein) and procaspase-8 to form the death-inducing signaling complex (DISC)

Rai, G.K., Kumar, P., Choudhary, S.M., Singh, H., Adab, K., Kosser, R., Magotra, I., Kumar, R.R., Singh, M., Sharma, R., Corrado, G., and Rouphael, Yo., Antioxidant potential of glutathione and crosstalk with phytohormones in enhancing abiotic stress tolerance in crop plants, Plants , 2023, vol

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ExpiCHO-S cells were transfected with pCAGGS-AIM with each mutation and cultured in ExpiCHO Expression Medium supplemented with ExpiCHOFeed and ExpiFectamine CHO Enhancer for 4 days in a 37 C incubator with a humidified atmosphere of 8% CO 2 in air on an orbital shaker