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In SUMMIT, tirzepatide reduced the composite of cardiovascular death or worsening heart-failure events by 38% (HR 0.62, 95% CI 0.410.95) and worsening HF events alone by 46% (HR 0.54, 95% CI 0.340.85), with a +6.9-point between-group improvement in the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), an 18-meter improvement in 6-minute walk distance (6MWD), and a placebo-adjusted weight loss of 11.6% [5]
Spironolactone inhibits the effects of aldosterone on the distal renal tubules
It is not willpower
On a test that measured changes in clinical dementia before and after treatment, there was no difference between the drug and the placebo
P =0.36)
[1] Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use semaglutide
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