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Oral probiotic administration during pregnancy prevents autismrelated behaviors in offspring induced by maternal immune activation via antiinflammation in mice

Mechanism of Action Nitric Oxide Synthase Pathway : L-citrulline works by converting to arginine through the urea cycle via argininosuccinate synthase and argininosuccinate lyase enzymes, then interacting with nitric oxide synthase (NOS) enzymes to generate nitric oxide and support the relaxation of blood vessel smooth muscle

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Liu C, Li B, Yan Q, Niu S, Zhao Y, Xiong C, et al

The closest human data is from CB4211, an analog that completed a Phase 1a/1b safety trial (NCT03998514) with well-tolerated SubQ dosing and favorable liver-enzyme and glucose trends

Contamination happens easily and ruins entire vials