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You should contact your GP if you experience any of the following: Periods that stop entirely for three months or more if your cycles were previously regular, or for six months or more if your cycles were previously irregular (secondary amenorrhoea) Unusually heavy or prolonged bleeding for example, bleeding that lasts more than seven days, passing clots larger than a 10p coin, flooding through protection every one to two hours, or needing to use double protection (in line with NHS and NICE NG88 guidance on heavy menstrual bleeding) [6] Severe pelvic pain associated with your cycle Spotting or bleeding between periods or after sexual intercourse Signs of nutritional deficiency , such as hair loss, fatigue, or brittle nails, which may suggest malabsorption (particularly relevant with orlistat use) It is also important to consider that missed periods are not always caused by weight loss or medication pregnancy should be excluded if there is any possibility of conception