Plainsboro, NJ: Novo Nordisk, Inc.;2019
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Though to our knowledge there are no studies on interactions between GLP-1 and CB1 receptors in the habenula, VTA or other brain regions, there is evidence of reciprocal functional interactions between these two receptors peripherally [57]
Adverse events that occurred in 20% or more of those receiving setmelanotide were skin hyperpigmentation (55.6%), nausea (50.6%), headache (39.5%), vomiting (39.5%), diarrhea (23.5%) and injection site reaction (23.5%)
Cardiovascular disease (CVD) is the main cause of death and disability among people with type 2 diabetes.[2] Adults with type 2 diabetes are two to four times more likely to develop CVD than adults without diabetes.[3] The FDA's decision on semaglutide is based on results from the SUSTAIN 6 cardiovascular outcomes trial (CVOT), which examined the cardiovascular safety of adding Ozempic or placebo to standard-of-care in adults with type 2 diabetes and established cardiovascular disease
An overdose may increase the risk of serious side effects, including seizures, rapid heart rate, very high blood pressure, or severe nausea and vomiting