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Type 2 diabetes | Treatment summaries BNF/NICE

Quick Answer: Accidentally taking a double dose of tirzepatide typically causes intensified gastrointestinal symptoms like severe nausea and vomiting, with hypoglycemia risk primarily in patients taking concurrent insulin or sulfonylureas

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Baker, A

Here are 8 potential reasons why not to prescribe Lixisenatide: 1- this is only one small study and only one dose was tested, 2- Lixisenatide is not currently available at pharmacies, 3- the weight loss associated with this GLP-1 is not desirable in many cases of Parkinsons disease where weight loss is an issue, 4- non-motor outcomes did not change as in other trials, and this will need to be better explained

Most commonly, this means insulin through multiple daily injections or an insulin pump, though some providers use metformin as an adjunct since its generally considered safe in pregnancy