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The following is one example of a titration schedule used in Phase 2 protocols it does not represent a single universal regimen, and other escalation speeds were also evaluated: Weeks 14: 2 mg once weekly (initiation dose) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Week 13 onwards: 12 mg once weekly (where tolerated) This gradual up-titration mirrors the approach used with approved agents such as semaglutide and tirzepatide, where slow dose escalation is essential to improve gastrointestinal tolerability

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However, its potential appears to be reduced when intervals are every 48 or 72 hours

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Drug-pathway interaction data were available for 50 out of the 57 DM2 DMTs, while seven DM2 DMTs (Pramlintide acetate, Dapagliflozin, Canagliflozin, Empagliflozin, Ertugliflozin, Luseogliflozin hydrate, and Colesevelam hydrochloride) lacked pathway associations in KEGG and were excluded from further analysis