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they use IGF-1 LR3 when targeting IGF-1 receptor effects in specific tissues without the upstream GH pathway
Juster RP, McEwen BS, Lupien SJ (2010)
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Additionally, VB6 deficiency has been linked to an increase in nuclear uptake and prolonged retention of steroid hormones, resulting in heightened sensitivity of target tissues to hormonal actions [61]
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These effects have been correlated with improvement in major depression
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