By precisely inhibiting NNMT, regulating the nicotinamide pathway, and maintaining NAD+ homeostasis, 5amino1mq injection plays an important role in research on glucose metabolism disorders and diabetes, particularly in insulin resistance mechanisms, glucose control validation, and diabetes complications
Data availability The datasets generated and analyzed during this study are included in the Supplementary files
NNMT is overexpressed in obese adipose tissue and is theorized to deplete SAM and NAD+ pools in adipocytes, contributing to metabolic dysfunction
As a membrane-permeable small molecule, 5 amino 1mq readily crosses cell membranes to reach its intracellular target
The distinct microbiome profile of 5A-1MQ-treated mice was also supported by k-means clustering
Short-term storage: Room temperature in a sealed container is acceptable for several months