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In the cytoplasm, Keap1 homodimer forms ubiquitin E3 ligase complex with cullin 3 (Cul3), which polyubiquitinates Nrf2 protein leading to its continuous proteasomal degradation ( Figure 3, right)
Standard over-the-counter treatment is sufficient if it occurs
3, June 2024, pp
[1] These reactions are usually mild and self-limiting
Moderate elevations in bilirubin levels have anti-diabetic effects
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