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Novo Nordisk first revealed headline figures from this study a year ago, with full results since published in the New England Journal of Medicine

decreased smooth muscle cell proliferation reduces neointimal formation Anti-inflammatory signaling: Suppression of NF-kB, reduced macrophage infiltration into plaques, and decreased secretion of IL-6, TNF-alpha, and MCP-1 from monocytes and foam cells Atherogenic lipid reduction: Improvements in LDL cholesterol, VLDL, triglycerides, and chylomicron remnants beyond what weight loss alone would predict Blood pressure reduction: Through direct vasodilation and natriuresis, independent of weight change Epicardial and perivascular fat reduction: This fat depot exerts direct paracrine inflammatory effects on the vascular endothelium and myocardium

As someone who has dedicated his career to understanding and treating alcohol use disorder, I recognize the significance of these findings, particularly given the current attention on the adverse health impact of heavy drinking, said Henry Kranzler, Professor of Psychiatry at the University of Pennsylvania Perelman School of Medicine and Principal Investigator of the RECLAIM trial

Most clients rest, read, or work during treatment

(1997a)