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Additionally, caloric restriction itself may contribute to cold sensitivity

- Before beginning treatment with orlistat, any organic cause of obesity should be excluded, such as untreated hypothyroidism

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If you indicate you have type 2 diabetes, the projection is adjusted based on the SURMOUNT-2 and STEP-2 trial data, which showed moderately lower average weight loss in this population 3,4

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10.1371/journal.pone.0181880 12 BnemannM.GerhardsteinB