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Technical challenges and biases in studying MuSC states Early responses of MuSCs to the disruption of their niche include increased expression of AP-1 members and ERK1/2 targets such as Fos and Jun, rapid downregulation of genes encoding Hox proteins, zinc finger proteins, metabolism enzymes, and Notch signaling [50,51,52, 54]

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Obesity rates have almost tripled since 1975, which researchers say is due to a combination of factors, including: Increased access to energy-dense food coupled with reduced physical activity Sleep deprivation Circadian desynchronization Chronic stress A rise in the use of certain medications known to result in weight gain, including some anti-epileptic and psychotropic drugs Other genetic and environmental factors As a result, prescription drug companies have sought their own way to target the treatment of obesity