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Similarly, it was studied whether PAS* had an effect on tryptophan metabolism in DSS-induced colitis, as gut microbiota-derived metabolites such as essential amino acid tryptophan (Trp) metabolites have been implicated in the pathogenesis of IBD [60]

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This offers a clear, mechanistic explanation for why so many dysautonomia patients report improved orthostatic tolerance and reduced tachycardia when incorporating mitochondrial shuttles into their daily treatment protocols