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Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit
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Daily, target 1.6 to 2.2 grams per kilogram of body weight
RR, midbrain reticular nucleus, retrorubral area
10.1016/j.cld.2017.08.014 17
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