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Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )

White blood cells from patients with COVID-19 activate brain endothelial cells Given the prevalence of circulating markers indicative of BBB dysfunction and immune cell activation, we examined gene expression changes in peripheral blood mononuclear cells (PBMCs) isolated from unaffected ( n = 7), recovered ( n = 5) and patients with long COVID with ( n = 6) or without ( n = 5) brain fog using RNA sequencing (RNA-seq)

Also focusing on ferroptosis, a novel mode of cell death

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