Additionally, some 3D systems are specifically designed to incorporate hemodynamic forces, such as shear stress and shear strain from blood flow, which can significantly influence cell behavior [225]
This is consistent with other findings showing a weakening in the antioxidant defences and oxidative DNA damage in the gut, liver, spleen, and lung of animals after sleep restriction
Furthermore, competing endogenous RNAs (ceRNAs) as essential miRNA-regulators have emerged as therapeutics scavenging oncogenic miRNAs
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