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N Engl J Med (2016) 375(16):155265

10.1183/23120541.00495-2022 ERJ Open Res

This reduction aligns with previous research by Harvie et al

The activation of the AGE-RAGE axis amplifies chronic inflammation and oxidative stress in both microenvironments, while SNS overactivity and elevated catecholamines induce vasoconstriction in both testicular and penile vasculature, forming a vicious cycle of sympathetic activation and inflammatory damage (207)

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The control of blood glucose may be driven by the presence of probiotic strains, particularly Lentiactobacillus spp