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Formulations of cyanocobalamin injection containing benzyl alcohol as a preservative should also be avoided in premature neonates and those with hypersensitivity due to its association with gasping syndrome (10-12)

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In a similar vein, co-incubation with L-carnitine, a quaternary amine that desensitizes the mPTP by reducing the transmembrane electrical potential, prevents the permeability transition of mitochondria exposed to colistin 48

Nonsense mutations have been found to be associated with the absence of any carnitine transport activity