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Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (to DK) and by a Grant-in-Aid for Young Scientists from Japan Society for the Promotion of Science (to YT)

Most available research is based on small, short-term human studies, animal models, or lab experiments not large-scale clinical trials

While brushing, take special care to thoroughly brush the back of the tongue where bacteria normally collects

Nam H, Lim JH, Kim TW et al (2023) Extracellular superoxide dismutase attenuates hepatic oxidative stress in nonalcoholic fatty liver disease through the adenosine monophosphate-activated protein kinase activation

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[] The transition to a Gram-negative bacterial environment from a Gram-positive bacterial population is favored by factors such as stagnant saliva, reduced availability of carbohydrate content as a bacterial substrate, and decreased salivary flow