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The Trial Numbers In Eli Lillys Phase 2 trial published in The New England Journal of Medicine in 2023: At the highest dose (12mg), participants lost an average of 24.2% of body weight at 48 weeks That compares to roughly 15% for semaglutide and 20% for tirzepatide Additionally, participants showed improvements in blood pressure, triglycerides, and blood sugar Side effects were similar to other GLP-1 class drugs: nausea, constipation, vomiting primarily in early weeks Phase 3 trials are ongoing

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Aromatase inhibitors block local estrogen produced by endometriotic tissues, thus destroying the focal feed-back for ectopic endometrial growth

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