GBM cells metabolize glucose, glutamine, lipids and tryptophan to create local nutrient competition and immunosuppression (105), leading to T-cell exhaustion and expansion of Tregs and immune-suppressive M2-like macrophages (106)
Using complex CRC GEMMs with proficient immune signalling, we demonstrate an increase in cell death and survival in these heterogeneous tumours, more akin to a tumour histology than xenograft or PDX counterparts 21,78
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The trial enrolled adults with overweight or obesity and randomised them to receive CagriSema, cagrilintide alone, semaglutide alone, or placebo over 32 weeks
78 These DAMPs act as danger signals that activate innate immune receptors, including pattern recognition receptors
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